Fluimucil Mucolytic 200mg Granules N-acetylcysteine 30 Sachets

Over-the-counter drug used for the treatment of respiratory diseases characterized by thick and viscous hypersecretion: acute bronchitis, chronic bronchitis and its exacerbations, pulmonary emphysema, mucoviscidosis and bronchiectasis. CONTRAINDICATIONS Hypersensitivity to the active substance or to any of the excipients. Generally contraindicated in pregnancy and lactation. PRECAUTIONS FOR USE Patients with bronchial asthma must be closely monitored during therapy, if bronchospasm occurs, treatment must be stopped immediately. The use of the medicinal product in patients with peptic ulcer or with a previous history of peptic ulcer requires particular attention, especially in the case of concomitant use of other drugs with a known gastric-damaging effect. INTERACTIONS Inform your doctor or pharmacist if you have recently taken any other medicines, even those without a prescription. DRUG-DRUG INTERACTION Drug-drug interaction studies have only been conducted in adult patients. Antitussive drugs and N-acetylcysteine should not be taken at the same time as the reduced cough reflex could lead to an accumulation of bronchial secretions. Activated carbon can reduce the effect of N-acetylcysteine. It is advisable not to mix other drugs with the Fluimucil solution. The information available on the antibiotic-N-acetylcysteine interaction refers to in vitro tests, in which the two substances were mixed, which showed a decreased activity of the antibiotic. However, as a precaution, it is recommended to take antibiotics by mouth at least two hours after the administration of N-acetylcysteine. It has been shown that the simultaneous intake of nitroglycerin and N-acetylcysteine causes significant hypotension and causes dilation of the temporal artery with possible onset of headache. If the simultaneous administration of nitroglycerin and N-acetylcysteine is necessary, patients should be monitored for the onset of hypotension, which can also be severe, and warned about the possible onset of headache. Drug-laboratory test interactions N-acetylcysteine can cause interference with the colorimetric assay method for the determination of salicylates. N-acetylcysteine can interfere with the test for the determination of ketones in urine. SPECIAL WARNINGS The presence of a sulphurous odor does not indicate any alteration of the preparation but is inherent in the active principle contained therein. The administration of N-acetylcysteine, especially at the beginning of the treatment, can thin the bronchial secretions and at the same time increase their volume. If the patient is unable to expectorate effectively, postural drainage and bronchoaspiration should be used to avoid secretion retention. PREGNANCY AND BREASTFEEDING Ask your doctor or pharmacist for advice before taking any medicine. Even if the teratological studies conducted with Fluimucil on animals did not show any teratogenic effect, however, as for other drugs, its administration during pregnancy and during the lactation period, should be carried out only in case of actual need under direct control. of the doctor. Effects on ability to drive and use machines There is no assumption or evidence that the drug can affect attention skills and reaction times. INFORMATION ON SOME EXCIPIENTS The granules for oral solution contain a source of phenylalanine which may be harmful in patients with phenylketonuria. The granules for oral solution contains sorbitol therefore patients with hereditary problems of fructose intolerance should not take this medicine. Sorbitol can have a laxative effect and its caloric value is 2.6 kcal / g. DOSE, METHOD AND TIME OF ADMINISTRATION Treatment of respiratory diseases 1 sachet per day (preferably in the evening). Possible dose adjustments may relate to the frequency of administration or dose splitting but must still be within the maximum daily dosage of 600 mg. The duration of therapy is from 5 to 10 days in the acute forms and in the chronic forms it will be continued, in the opinion of the doctor, for periods of a few months. Accidental or voluntary intoxication with paracetamol Orally, starting dose of 140 mg / kg body weight to be administered as soon as possible, within 10 hours of taking the toxic agent, followed every 4 hours and for 1-3 days by single doses of 70 mg / kg of weight. UROPATHY FROM ISO AND CYCLOPHOSPHAMIDE In a typical course of chemotherapy with iso and cyclophosphamide of 1,200 mg / m2 of body surface area per day for 5 days every 28 days, N-acetylcysteine can be administered orally at a dose of 4 g / day in the days of chemotherapy treatment distributed in 4 doses of 1 g. INSTRUCTIONS FOR USE Dissolve the contents of a sachet in a glass containing a little water, stirring as needed with a spoon. OVERDOSE Overdose can cause gastrointestinal symptoms such as nausea, vomiting and diarrhea. In case of accidental ingestion / intake of an excessive dose of FLUIMUCIL, notify your doctor immediately or go to the nearest hospital. If you have any questions on the use of Fluimucil, ask your doctor or pharmacist.