Zerinolflu Effervescente Analgesico e Antipiretico 20 Compresse Effervescenti

Effervescent tablets based on paracetamol, chlorphenamine maleate and Vitamin C.

Therapeutic indications

Zerinolflu is used in the treatment of flu and cold symptoms in adults.

Dosage and Posology

Administer Zerinoflu according to the following doses:

• Adults: 1 effervescent tablet twice a day.
• Pediatric population: The safety and efficacy of Zerinolflu in patients below 18 years of age has not been established.

Patients should be advised to contact their physician if fever persists or symptoms do not improve after 3 days of treatment

How to use

The effervescent tablet should be dissolved in about half a glass of water. The medicine should be taken after meals.

Overdose

In case of overdose, marked depressive or stimulating effects on the central nervous system, somnolence, lethargy, respiratory depression are generally observed.
In case of overdosing, the paracetamol contained in Zerinolflu can cause hepatic cytolysis which could evolve towards massive necrosis.

N-acetylcysteine, administered in the hours immediately following paracetamol ingestion, is effective in limiting liver damage. It is recommended that the usual measures be used to remove non-absorbed material from the gastrointestinal tract by inducing vomiting or possibly by gastric lavage; keep the patient under observation by practicing supportive therapy. Further measures will depend on the severity, nature and course of the clinical symptoms and should follow standard intensive care protocols.

Contraindications

• Hypersensitivity to paracetamol, to chlorphenamine or ascorbic acid, to any of the excipients or to other closely related substances from a chemical point of view, in particular antihistamines with a chemical structure similar to chlorphenamine.
• Pregnancy and breastfeeding;
• Patients with manifest insufficiency of glucose-6-phosphate dehydrogenase and patients with severe haemolytic anemia;
• Severe hepatocellular insufficiency (Child-Pugh C);
• Glaucoma, prostatic hypertrophy, bladder neck obstruction, pyloric and duodenal stenosis or other tracts of the gastrointestinal and urogenital tracts, due to anticholinergic effects;
• Patients being treated with monoamine oxidase inhibitors (MAOIs) or in the two weeks following such treatment.
  
  

Side effects

Following the use of Zerinolflu, the following side effects may occur. The frequency of these undesirable effects cannot be estimated from the available data.

• Blood and lymphatic system disorders: thrombocytopenia, leukopenia, anemia, agranulocytosis, pancytopenia
• Immune system disorders: hypersensitivity reactions such as angioedema, laryngeal edema, anaphylactic shock
• Nervous system disorders: somnolence, asthenia, dizziness, headache, inability to concentrate
• Eye disorders: blurred vision
• Respiratory, thoracic and mediastinal disorders: thickening of bronchial secretions
• Gastrointestinal disorders: dry mouth, nausea
• Hepatobiliary disorders: impaired liver function and hepatitis
• Skin and subcutaneous tissue disorders: Skin reactions of various types and severity have been reported with the use of paracetamol including cases of urticaria, erythema multiforme, very rare cases of severe skin reactions such as Stevens-Johnson syndrome (SJS), necrolysis epidermal toxicity (TEN) and acute generalized exanthematous pustulosis (AGEP). Photosensitization.
• Renal and urinary disorders: renal disorders (acute renal failure, interstitial nephritis, haematuria, anuria), urinary retention.

Pregnancy and breastfeeding

Zerinolflu is contraindicated during pregnancy and lactation.

Special warnings

Do not administer for more than 3 consecutive days without consulting your doctor. If the fever persists for more than three days or if symptoms do not improve and others appear within three days or are accompanied by a high fever, rash, excessive mucus and persistent cough, consult your doctor before continuing administration.

During treatment with Zerinolflu ensure that no other medicines containing paracetamol are taken at the same time, as if paracetamol is taken in high doses, serious adverse reactions can occur. Instruct the patient to contact the physician before associating any other medication. High or prolonged doses of the product can cause high-risk liver disease and even serious changes in the kidney and blood. In case of acute hypersensitivity reactions to paracetamol (e.g. anaphylactic shock), treatment with Zerinolflu should be discontinued and necessary medical measures based on the signs and symptoms.

At common therapeutic doses, antihistamines exhibit highly variable secondary reactions from subject to subject and from compound to compound. The most frequent secondary effect is sedation which can manifest itself as drowsiness; those who may drive motor vehicles or attend to operations that require integrity of the degree of supervision must be warned of this.

Ascorbic acid (vitamin C) should be used with caution by people who suffer, or have suffered in the past, from nephrolithiasis (kidney stones) and by those with G6PD (Glucose-6-phosphate-dehydrogenase) deficiency, hemochromatosis, thalassemia or sideroblastic anemia.

Administer with caution in subjects with renal or hepatic insufficiency.

Particular attention should be paid to determining the dose in the elderly due to their greater sensitivity to the drug. Effects such as dizziness, sedation, confusion and hypotension are more likely to occur in elderly patients being treated with antihistamines. Elderly patients are particularly sensitive to the anticholinergic side effects of antihistamines such as dry mouth and urinary retention (especially in men).

Zerinolflu effervescent tablets contains

• Aspartame

This medicine contains a source of phenylalanine. It can be harmful if you have phenylketonuria (lack of the enzyme phenylalanine hydroxylase).

• Sorbitol

Patients with rare hereditary problems of fructose intolerance should not take this medicine.

• Sodium

One effervescent tablet contains 14.83 mmol of sodium. To be taken into consideration in patients with impaired renal function or on a low sodium diet.

Expiry and Retention

Do not store above 25 ° C.

Warning : do not use Zerinol flu after the expiry date stated on the package

Composition

One effervescent tablet of Zerinol flu contains:

Active principle

Paracetamol 300 mg, chlorphenamine maleate 2 mg, sodium ascorbate 280 mg corresponding to ascorbic acid (vitamin C) 250 mg.

Excipients

Anhydrous citric acid, sodium bicarbonate, sodium carbonate, sorbitol, povidone, dimethicone, aspartame, orange flavor, lemon flavor.