Longlife 5-HTP 60cps

5-HTP

Griffonia

MOOD, SLEEP AND APPETITE

Product Information

Each capsule contains

Griffonia seeds 500 mg

(Griffonia simplicifolia Dc. Bai / l.)

hydroalcoholic dry extract (10/15: 1) titrated

20% (100mg] 5-HTP

maltodextrin, anti-caking agents (vegetable magnesium stearate and silicon dioxide). Capsule of vegetable origin in hydroxypropylmethylcellulose

5-HTP (5-hydroxytryptophan), natural amino acid precursor of the neutotransmitter serotonin and intermediate of tryptophan metabolism, participates in the regulation of mood, sleep, emotions, appetite and cognitive functions .

Tryptophan, precursor of 5-HTP and serotonin, is contained in numerous foods, particularly in meats and dairy products, however only 3% exceeds the blood brain barrier to be used, compared to 70% of 5 - HTP. main of 5-HTP we find the seeds of an African legume (Griffonia simplicifolia). The psychoactive activity of 5-HTP appears to depend on its action on the synthesis of serotonin in the CNS. 5-HTP stimulates the serotonergic neurons to increase the production and consequently the release of serotonin .

Depression and mood swings

Reduced levels of 5-HTP have been observed in depressed patients in numerous clinical studies. In an experiment conducted in France in 28 (out of 36) subjects suffering from severe depression and treated with 5-HTP were reported positive results.

Improvements in depressive symptoms were observed in 24 patients hospitalized for depression treated with 5-HTP in a Japanese study. In a double-blind study of 59 depressed patients treated with 150-300 mg / day for 3 weeks, there was a positive response in 90 subjects (67.8%), 13 of which with marked improvement. 80% of responders achieved improvement in week 1.

Appetite control

The slimming effect of 5-HTP is given by the fact that, in the form of serotonin, it inhibits the hunger signal, reduces the desire for carbohydrates and improves mood, increasing the basal calorie consumption. Body weight decreases, in relation to placebo, occurred at dosages of 800-900 mg / day in a few weeks, in percentages varying between 2 and 5%, without alteration of mood.

In a double-blind placebo study involving 19 obese subjects, taking 5-HTP (8 mg / kg / day) for 5 weeks resulted in a 504 weight loss compared to the control group. A subsequent 12-week experiment obtained the same results.

In another study, 20 overweight women were given 900 mg / day of 5-HTP, or placebo, for 6 weeks. At the conclusion of the study, a reduction in body weight (2-5%) was observed in the group that had taken 5-HTP, but not in the placebo group. Similar benefits were

500 mg

20% 5-Hydroxytryptophan

observed in a double-blind study of 14 overweight women (900 mg / day).

Migraine, headache

Low serotonin levels can cause chronic headaches and migraines115-HTP has been used successfully in the prevention of chronic headaches of various types, including tension-type migraines. In one study 124 patients were treated with 5-HTP (600 mg / day) or methysergide (migraine medicine) for 6 months. Significant improvement was observed in 75% of patients treated with methysergide and in 71% of those treated with 5-HTP115-HTP reduced attack intensity and duration, rather than frequency, showing greater tolerability.

In another study of 48 children (6-13 years), the intake of 4.5 mg / kg / day of 5-HTP produced a 70% reduction in the frequency of migraines, compared to 1% in the placebo group. .

Insomnia

5-HTP is effective in treating insomnia, particularly in improving sleep quality in REM sleep. 5-HTP is converted directly into melatonin, therefore, some of the sleep-induced effects of 5-HTP are the result of increased melatonin levels

Some French researchers have observed that the administration of 100 mg / day of 5-HTP to subjects suffering from mild insomnia, was able to induce significant improvements in sleep quality.

In a study of children suffering from nightmares and persistent night fears, the administration of 2 mg / kg / day of 5-HTP over 6 months produced remission of the disorder in 83% of the children treated.

Psychostimulant abuse

Amphetamine and cocaine damage the integrity of the serotonergic neurons of the CNS Some studies indicate a potential use of 5-HTP for dosed or chronic psychostimulant users, in particular amphetamine, methamphetamine, cocaine The greatest benefits concern the improvement of associated cognitive deficits abuse of these substances.

Fibromyalgia

There have been good results in analgesic activity in subjects suffering from fibromyalgia. Studies are underway to improve dosages and toxicity.

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