Bioimmunas Plus Immune Defense Supplement 24 Sachets

BIOIMMUNAS
PLUS Food supplement with extracts of morinda citrifolia, sambucus nigra, ribes nigrum, echinacea angustifolia and lactic ferments with antioxidant activity and immunostimulating properties, adjuvant in the treatment and prevention of seasonal infections of the upper respiratory tract and useful in conditions of decreased immune defenses, in pediatrics and during chronic and neoplastic diseases.
Lactoferrin
Its main action is to stimulate the immune system. Lactoferrin is a glycoprotein (the human one is made up of 691 AA) which binds 2 Fe2 + atoms; it is present in breast milk and in many secretions (tears, nasal exudate, saliva, bronchial secretions, gastro-intestinal juice, cervico-vaginal mucus and seminal fluid) it is also synthesized in the white blood cells which release it in the sites where there is an infectious process. Immunostimulating action: it is able to promote the growth and differentiation of T helper, CD4 and CD8 lymphocytes which in turn stimulate the antibody response by B lymphocytes; it also seems to have an important role in the release and regulation of all those chemical mediators (cytokines, interleukins, lymphokines and TNFs) involved in recalling the cells of the immune system in the event of infections or inflammation. Antibacterial action: since it does not make available free iron, an essential element for promoting the growth of pathogenic bacteria, it makes these species more vulnerable to the action of antibiotics (an important example is given by the easier eradication of Helicobacter Pylori obtainable with taking lactoferrin during antibiotic therapy); in addition, a derivative of lactoferrin itself (lactoferricin which derives from the enzymatic digestion of lactoferrin) seems to have its own antibacterial action.
Morinda Citrifolia L (Noni)
Equipped with numerous biological activities, among which immunomodulating, antibacterial, antiviral, anti-inflammatory and analgesic ones are of particular interest. The major components derived from the fruit and leaves include: terpenoids, flavonoids, linoleic acid, β sitosterol, scopoletin, ursolic acid, proxeranine.
Ribes Nigrum L.
The extract of black currant juice rich in mineral salts, vitamin C and phenolic components has a documented antioxidant, immunomodulating and antimicrobial activity. Studies carried out in vitro demonstrate a stimulating action on macrophages and innate immunity. Active components: phenolic components such as anthocyanins, flavonoids, ellagitannins, gallotannins, proanthocyanidins, phenolic acids and polysaccharide extracts.
Probiotics
The supply of lactic ferments is a fundamental aid in all situations of altered balance of the intestinal microflora. Bioimmunas Plus provides complete and balanced support of freeze-dried lactic ferments associated with the positive effect of FOS as prebiotics and Vitamin C.
Echinacea angustifolia
Provided with stimulation activity of innate and adaptive immunity through the phagocytic stimulation of macrophages and the release of cytokines including interferon-gamma, carrying out an adjuvant activity in opportunistic infections and in rhinovirus infections and in viral diseases of the upper respiratory tract. Active components: alkamidic derivatives and caffeic acid.
Sambucus Nigra L.
Known for its antioxidant, antiviral, antiproliferative (in vitro) and antimicrobial properties, Elderberry has an immunostimulating and antioxidant action and is able to assist in the course of colds and flu (in vitro studies demonstrate H1N1 anti virus activity) by stimulating the production of anti-inflammatory and pro-inflammatory cytokines with immunoprotective action. The extract of Elderberry is useful in subjects with decreased efficiency of the immune system, in pediatrics and during various infectious and neoplastic pathological conditions. Active components: polyphenols derived from the fruit, including flavonoids (hyperoside, isoquercitin and rutoside) and anthocyanins.

Ingrediants

	per sachet of 3.7 g	per 100 g
NONI (juice)	250 mg	6.76 g
Black currant buds	150 mg	4.05 g
Echinacea es 4%	100 mg	2.7 g
Elderberry 0.3%	100 mg	2.7 g
Lactic ferments of which: L. acidophilus (DSM20079) L. casei (DSM20011) L. rhamnosus (SGL06) B. bifidum (DSM20456)	61 mg 2 billion 1.5 billion 1.5 billion 1 billion	1.65 g
Lactoferrin	15 mg	0.41 g

How to use
Children: one sachet a day to be dissolved in half a glass of water or fruit juice.
Adults: two sachets a day (one in the morning and one in the evening) to be dissolved in half a glass of water.
To be taken preferably on an empty stomach.

Warnings
Do not exceed the recommended daily dose.
Keep out of the reach of children under three years of age.
Supplements are not intended as a substitute for a varied diet.
For pregnant or lactating women and children it is recommended to seek medical advice.

Format
Box of 24 sachets of 3.7 g.

Bibliography
- The effect of Sambucol, a black elderberry-based, natural product, on the production of human cytokines: I. Inflammatory cytokines Barak V, Halperin T, Kalickman I. Eur Cytokine Netw. 2001 Apr-Jun; 12 (2): 290-6.
- A systematic review on the sambuci fructus effect and efficacy profiles Vlachojannis JE, Cameron M, Chrubasik S. Phytother Res. 2010 Jan; 24 (1): 1-8. Review.
- Immunostimulatory effects of a polysaccharide-rich substance with antitumor activity isolated from black currant (Ribes nigrum L.). Takata R, Yamamoto R, Yanai T, Konno T, Okubo T. Biosci Biotechnol Biochem. 2005 Nov; 69 (11): 2042-50.
- Anti-angiogenic, antioxidant, and anti-carcinogenic properties of a novel anthocyanin-rich berry extract formula. Bagchi D, Sen CK, Bagchi M, Atalay M. Biochemistry 2004 Jan 69 (1): 75-80.
- Berry fruits: compositional elements, biochemical activities, and the impact of their intake on human health, performance, and disease. Seeram NP.J Agric Food Chem. 2008 Feb 13; 56 (3): 627-9