Efferalgan 500mg 16cpr Effervescenti

Symptomatic treatment of mild to moderate pain and febrile conditions in adults and children and in the symptomatic treatment of arthritic pain.

Dosage and method of use
Efferalgan Tablets are administered for oral use. The tablets should be swallowed whole with a glass of water.

Efferalgan Tablets are reserved for adults and children weighing more than 26 kg (approximately 8 years or more). In children, the dosage regimens based on body weight must be respected and therefore the suitable formulation must be chosen. The correspondence between age and weight is only indicative.

Children weighing between 26 kg and 40 kg (aged between 8 and 13 years approximately): the dosage is 1 tablet for each administration, to be repeated, if necessary, after an interval of at least 6 hours, without exceeding 4 tablets per day.
Adolescents weighing between 41 kg and 50 kg (aged between 12 and 15 years approximately): the dosage is 1 tablet each administration, to be repeated, if necessary, after an interval of at least 4 hours without exceeding 6 tablets per day.
Adults and adolescents weighing more than 50 kg (about 15 years or more): the usual unit dosage is one tablet for each administration, to be repeated, if necessary, after an interval of at least 4 hours without exceeding 6 tablets per day.
Adults: in case of more intense pain, two tablets can be taken at a time for a maximum of 3 times a day (3 g of paracetamol), always respecting an interval of at least 4 hours between doses.
Regular administrations prevent fluctuating pain or fever levels.

In children, the interval between administrations should be regular, both day and night, and should preferably be at least 6 hours.
in adults and adolescents, an interval of at least 4 hours between administrations must always be respected.
In case of severe renal insufficiency (creatinine clearance less than 10 ml / min), the interval between dosing should be at least 8 hours. Do not exceed 3 g of paracetamol per day, i.e. 6 tablets

Contraindications
Hypersensitivity to paracetamol or propacetamol hydrochloride (precursor of paracetamol) or to any of the excipients

Special warnings
Paracetamol should be administered with caution to patients with mild to moderate hepatic insufficiency (including Gilbert's syndrome), severe hepatic insufficiency (ChildPugh> 9), acute hepatitis, concomitant treatment with drugs that impair liver function, glucose deficiency -6-phosphate dehydrogenase, haemolytic anemia.

Do not administer during chronic treatment with drugs that can determine the induction of hepatic monooxygenases or in case of exposure to substances that can have this effect. Paracetamol should be administered with caution in subjects with renal insufficiency (creatinine clearance ≤ 30 ml / min). Use with caution in case of chronic alcoholism, excessive alcohol intake (3 or more alcoholic drinks per day), anorexia, bulimia or cachexia, chronic malnutrition (low reserves of hepatic glutathione), dehydration, hypovolemia.

Pregnancy and breastfeeding
Clinical experience with the use of paracetamol during pregnancy and lactation is limited.

Pregnancy
Epidemiological data on the use of therapeutic doses of oral paracetamol indicate that no undesirable effects occur in pregnant women or on the health of the fetus or neonates. Reproductive studies with paracetamol did not reveal any malformation or foetotoxic effects. However, paracetamol should only be used during pregnancy after a careful evaluation of the risk / benefit ratio.
Feeding time
Paracetamol is excreted in breast milk in small quantities. Rash has been reported in breast-fed infants. However, the administration of paracetamol is considered compatible with breastfeeding. However, caution should be used when administering paracetamol to breastfeeding women.

Composition
Efferalgan Tablets contains:
Active ingredient: paracetamol 500 mg
Excipients: Hypromellose, povidone, croscarmellose sodium, glyceryl behenate, microcrystalline cellulose, magnesium stearate.

Pack of 16 effervescent tablets for oral use