Mioven 700 supplement for the microcirculation 20 tablets

MIOVEN
700 Dietary supplement based on diosmin, sweet orange (hesperidin), butcher's broom. MIOVEN 700 provides the useful elements for the maintenance of the physiological venous circulation (functionality of the haemorrhoidal plexus) and for the physiological functionality of the microcirculation (heaviness of the legs).
Gluten free. Lactose-free. Sugar free.
Diosmin
It exerts a double action on the capacitance vessels: at the level of the veins and venules, it increases the parietal tone and exerts an anti-venous stasis action, while at the level of the microcirculation it increases the resistance of the capillaries and normalizes their permeability, making them less fragile . The protective effect of diosmin against vascular damage is also expressed through the inhibition of the release of inflammatory mediators (prostaglandins, free radicals, cytokines) by polymorphonuclear cells and macrophages ¹ .
Hesperidin
It reduces the excessive vascular permeability of capillaries and increases the resistance of the endothelium ² .
Rusco
Recommended for the treatment of problems associated with chronic venous insufficiency, such as pain, heaviness, leg cramps, swelling and itching. ³ Ruscogenin activates microcirculation and preserves skin integrity through various mechanisms. Ruscogenin reduces cell permeability due to its anti-elastase activity. Elastase is an enzyme that degrades elastin, a major component of venous elastic fibers. Collagen and elastin are the main components of the extracellular matrix. The anti-elastase activity of ruscogenin avoids the degradation of the perivascular components and thus reduces cell permeability. The ruscogenic also possesses vasoconstrictive properties, through adrenergic mechanisms. ^4-5

Ingrediants
Diosmin; sweet orange (hesperidin); rusco.

How to use
2 tablets per day in the attack phase and 1 tablet per day in the maintenance and / or prevention phase.

Warnings
It can be taken by the diabetic, the celiac, the lactose intolerant. Do not exceed the recommended daily dose. Keep out of the reach of children under 3 years of age. Supplements are not intended as a substitute for a varied diet.

Format
20 tablets in blister pack.

Bibliography
- 1. Smith PD. Neutrophil activation and mediators of inflammation in chronic venous insufficiency. J Vasc Res 1999; 36: 24-36.
- 2. Manthey JA. Biological properties of flavonoidspertaining to inflammation. Microcirculation2000; 7: S29-S34.
- 3. Phytotherapy. Rational use of plant drugs, Capasso Francesco, Grandolini Giuliano, Izzo Angelo A
- 4. Monograph Ruscus aculeatus (Butcher's Broom) Alternative Medicine Review Volume 6, Number 6. 2001.
- 5. Pharmacological assessment of adrenergic receptor in human varicose veins. Miller VM et al. Int. Angiol. 19: 176-183. 2000.