Vectra 3d Spot-on Soluzione 3 Pipette 8ml 436mg + 38,7mg + 3.175mg Cani > 40 Kg, Tappo Rosso

NAME
VECTRA 3D

PHARMACOTHERAPEUTIC CATEGORY
Topical ectoparassicides.

ACTIVE PRINCIPLES
Dinotefuran, pyriproxyphene, permethrin.

EXCIPIENTS
N-octyl-2-pyrrolidone, N-methylpyrrolidone.

INDICATIONS
Fleas: treatment and prevention of flea infestation (Ctenocephalides felis and Ctenocephalides canis). The treatment prevents flea infestation for one month. It also prevents the multiplication of fleas for two months after application by inhibiting the opening of the eggs (ovicidal activity) and inhibiting the appearance of adults from eggs laid by adult fleas (larvicidal activity). The veterinary medicinal product can be used as part of a treatment strategy for flea allergy dermatitis (FAD). Ticks: the veterinary medicinal product has persistent acaricidal efficacy and repellent action against tick infestations (Rhipicephalus sanguineus and Ixodes ricinus for one month, and Dermacentor reticulatus for up to three weeks). If ticks are present when the veterinary medicinal product is applied, they may not all be killed within the first 48 hours but may die within a week. To remove ticks, the use of a special device for removing ticks is recommended. Sand flies, mosquitoes and flies: treatment provides persistent repellent (anti-feeding) activity. Prevents bites from sand flies (Phlebotomus perniciosus), mosquitoes (Culex pipiens, Aedes aegypti) and flies (Stomoxys calcitrans) for one month after application. The treatment also provides persistent insecticidal activity for one month against mosquitoes (Aedes aegypti) and flies (Stomoxys calcitrans).

CONTRAINDICATIONS / SECONDARY EFFECT
Do not use in case of hypersensitivity to one or more active ingredients or to one of the excipients. Do not use on cats. Due to their particular physiology and inability to metabolise permethrin, this veterinary medicinal product should not be used on cats. If applied to a cat, or ingested by a cat that has been actively rubbing itself on a recently treated dog, this veterinary medicinal product can cause serious harmful reactions.

USE / ROUTE OF ADMINISTRATION
Topical.

DOSAGE
The minimum recommended dose is 6.4 mg dinotefuran / kg body weight, 0.6 mg pyriproxyphene / kg body weight and 46.6 mg permethrin / kg body weight, equivalent to 0.12 ml of the veterinary medicinal product per kg body weight. . Use the appropriate packaging according to the animal's body weight. Care should be taken to apply the veterinary medicinal product only to intact skin. Avoid superficial application to the dog's coat. Treatment scheme: following a single application, the veterinary medicinal product will prevent infestation for one month. The treatment can be repeated once a month.

STORAGE
This veterinary medicinal product does not require any special storage conditions.

WARNINGS
All dogs in the house must be treated. House cats should only be treated with a veterinary medicinal product authorized for use in that species. Fleas can infest the dog's basket, kennel and usual resting areas such as rugs and sofas and armchairs. In case of massive flea infestation and at the beginning of control measures, these areas should be treated with an appropriate insecticide and then vacuumed regularly. This veterinary medicinal product in cats can induce convulsions which can be fatal, due to the particular physiology of this species which is unable to metabolise some compounds, including permethrin. In case of accidental exposure, if unwanted effects appear, wash the cat with shampoo or soap. To prevent cats from accidentally coming into contact with this veterinary medicinal product, keep cats away from treated dogs until the application site is dry. It is important to ensure that cats do not rub on the application site of a dog that has been treated with this veterinary medicinal product. The safety of this veterinary medicinal product has not been proven in dogs less than 7 weeks of age or in dogs weighing less than 1.5 kg. Care should be taken to avoid contact between this veterinary medicinal product and the dog's eyes. Attack of a single tick after treatment cannot be ruled out. For this reason the transmission of infectious diseases cannot be completely excluded if conditions are favorable. The veterinary medicinal product remains effective when treated animals are immersed in water (e.g. when swimming, bathing). Immersion in water repeated weekly for a month and starting from 48 hours after treatment, as well as shampooing 2 weeks after treatment, has no effect on the effectiveness of this product. However, the duration of efficacy may be reduced by frequent shampooing, or bathing within 48 hours after treatment. Special precautions to be taken by the person administering the product to animals: Do not eat, drink or smoke when handling the veterinary medicinal product. Wash hands thoroughly and immediately after use. This veterinary medicinal product causes eye and skin irritation. Avoid contact with the skin. In case of accidental spillage on the skin, wash immediately with soap and water. If the veterinary medicinal product accidentally comes into contact with the eyes, they should be rinsed thoroughly with water. If eye or skin irritation persists, or if the veterinary medicinal product is accidentally ingested, seek medical advice immediately and show the package leaflet or the label to the physician.People with known hypersensitivity to any of the components should avoid contact with the veterinary medicinal product. Children should not touch treated dogs for at least four hours after administration of the veterinary medicine. It is therefore advisable to treat dogs in the evening, or before taking them for a walk. On the day of treatment, treated dogs should not be allowed to sleep with their owners, especially children. Used applicators should be disposed of immediately and not left in sight and reach of children. Wait for the application site to dry before allowing treated dogs to come into contact with fabrics or objects. Other Precautions: Treated dogs should not be allowed to enter water for 48 hours after treatment to avoid adverse reactions to aquatic organisms. Overdose: Except for erythema and changes in coat appearance, no adverse reactions were observed in healthy puppies aged 7 weeks, treated topically 7 times at 2 week intervals and up to 5 times the maximum recommended dosage. In case of accidental ingestion at the maximum recommended dosage, vomiting, salivation and diarrhea may appear but should disappear without treatment. Incompatibility: do not mix with other veterinary medicinal products and do not apply together with other veterinary medicinal products simultaneously and at the same site.

WAITING TIME
Not relevant.

TARGET SPECIES
Dogs.

INTERACTIONS
None known.

SIDE EFFECTS
Transient erythema, pruritus or other signs of application site discomfort which usually disappear spontaneously within 24 hours after administration of the product have been reported very rarely (less than 1 animal in 10,000 animals, including isolated reports). Gastrointestinal symptoms such as vomiting or diarrhea have also been reported very rarely. Transient aesthetic effects (greasy, matted appearance and build-up) have been reported very rarely at the application site, however these effects are usually no longer visible after 48 hours.

PREGNANCY AND BREASTFEEDING
The safety of the veterinary medicinal product in bitches has not been established during pregnancy and lactation. The use of the veterinary medicinal product in pregnant and lactating bitches or in dogs intended for breeding should be based on a benefit / risk assessment. Laboratory studies, with each of the components, dinotefuran, pyriproxyphene or permethrin, in rats and rabbits did not show any maternotoxic, teratogenic or fetotoxic effects. Dinotefuran has been shown to cross the blood-breast barrier and is excreted in milk. N-methylpyrrolidone, an excipient of the veterinary medicinal product, has been shown to be teratogenic in laboratory animals.